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20% POPUST NA IZDELKE VIDERMINA V LEKARNAH LJUBLJANA

SEDAJ 20% POPUST NA IZDELKE VIDERMINA V LEKARNAH LJUBLJANA

V ČASU OD 22.6. DO 4.9. OZ DO RAZPRODAJE ZALOG V NAVEDENEM TERMINU. 

INTIMNA NEGA ZA ŽENSKE VSEH STAROSTI - CELOSTNA TERAPIJA PRI VNETJIH INTIMNEGA PODGROČJA TER VSAKODNEVNA NEGA.

PANTHEXYL NOSNO PRŠILO - OZADJE UPORABE IN OCENJEVANJE KLINIČNIH PODATKOV

Izpiranje s hipertonično morsko vodo bo povzročilo osmozno pomikanje tekočine od vnetega predela proti hipertonični raztopini. Rezultat osmoze je zmanjšanje prostornine preobremenjene sluznice, kar zmanjša obseg edemov in težave z dihanjem.

 

Poleg tega kombinacija hipertonične morske vode s ksilitolom in pantenolom nadalje izboljšuje stanje subjekta.

 

Ksilitol je alkoholna oblika ksiloze, pentoznega sladkorja. Ker sta izraza lahko zamenljiva, se termin "ksilitol/ksiloza" tu torej uporablja za pomene "ksilitol", "ksiloza" in pa "ksilitol in ksiloza". Ksilitol, ksiloza in pa mešanice ksilitola in ksiloze so enakovredni ter vsi enako učinkoviti v enakih količinah pri vseh terapevtskih postopkih, ki so opisani tukaj.

 

Ksilitol je praviloma prisoten v kemijskih reakcijah tkiva, ima pa enake lastnosti in toksičnost kot namizni sladkor[i]. Na podlagi meritev količine izločenega ksilitola v urinu skupine ljudi iz južne Evrope, ki jim primanjkuje poseben encim, je Touster[ii] pripomnil, da človeško telo porabi med 5 in 15 gramov ksilitola na dan. Ksilitol je odobrila FDA kot živilski aditiv in se pogosto uporablja kot sladilo, predvsem v žvečilnih gumijih. Ko je zaužit skozi usta, se ksilitol absorbira v 90 % (predvsem v teščem črevesu) in se hitro presnavlja.

 

Ksilitol je bil temeljito raziskan v povezavi z zmanjševanjem zobnega kariesa glede na svoj vpliv na Streptococcus mutans, eno od bakterij, ki povzročajo kariozne obloge. Te študije so pokazale, da delovanje ksilitola/ksiloze spodbuja zaščito pred kariesom, tako da bakterije šibi in zmanjšuje njihov oprijem na zobne obloge[iii]. Paul Naaber[iv] je primerljivo zmanjšanje bakterijskega oprijema pokazal z dodajanjem ksilitola/ksiloze pri zdravljenju črevesnih okužb Clostridium difficile.

 

Leta 1998 je Kontiokari[v] izjavil, da 2,5-% raztopina ksilitola/ksiloze zmanjšuje bakterijski oprijem, kadar se uporablja za nosno sluznico; poleg tega so se ob uporabi 5-% raztopine glavni povzročitelji pljučnice zmanjšali za dve tretjini.

 

Leta 1999 so pri Doctor Jonesu patentirali[vi] pršilo (Xlear), ki vsebuje ksilitol, prečiščeno vodo, sol in pa ekstrakt semen grenivke kot konzervans. Razpršilo je bilo namenjeno za odstranjevanje bakterij in škodljivih snovi ter je blagodejno in vlažilno vplivalo na nosno sluznico.

 

Po tej teoriji razpršilo deluje na tri načine:

zmanjšuje oprijem bakterij na sluznico s pomočjo fizičnega mehanizma;

s pomočjo ksilitola stimulira obrambno dejavnost nosnih celic[vii] .

zmanjšuje koncentracijo soli v sluzi dihalnega trakta.

 

Na osnovi ocenjene literature lahko torej sklepamo, da so monosaharidi zmožni ovirati oprijem določenih bakterij, ki so lahko prisotne v ustni in nosni votlini.

 

D-pantenol (imenovan tudi "dekspantenol") je stabilnejša oblika pantotenske kisline ali vitamina B5. Pantenol igra ključno vlogo pri človeški presnovi, pomanjkanje vitamina B5 pa lahko povzroči različne kožne bolezni.

V kozmetiki ima uporaba pantenola prednost pred pantotensko kislino zaradi večje stabilnosti alkoholne oblike. Pantenol ima kemične in fizikalne lastnosti, zaradi katerih je enostaven za uporabo, npr. topnost v vodi in etanolu. Zaradi svojega pomembnega vlažilnega, mehčalnega in pomirjujočega delovanja je to izbrana sestavina v mnogih dermo-kozmetičnih izdelkih proti suhi in/ali razdraženi koži.

 

Na podlagi zgornjih podatkov lahko glede posameznih komponent hipertoničnega razpršila Tonimer s ksilitolom in pantenolom zaključimo, da lahko uporaba ksilitola v fiziološki raztopini kot pršilo za nos zagotavlja preverjene prednosti pri osebah z nazofaringitisom.

 

Ksilitol zares pomaga defenzinom zaradi svoje majhne transepitelijske prepustnosti, ki mu omogoča, da zmanjša koncentracijo soli v sluzi. Na ta način bakterije izgubijo sposobnost oprijema na tkivo sinusov, kar telesu omogoča, da jih lažje odstrani[viii] .

 

Dnevna uporaba pršila za nos s ksilitolom telesu pomaga, da "spere" stran bakterije, ki lahko povzročijo okužbe, prisotnost pantenola pa zagotavlja boljšo hidracijo in blagodejno vpliva na razdraženo sluznico.

 

Uporaba tega razpršila zmanjšuje bakterijske obremenitve v nazofarinksu; ker bakterij ne ubije, te pa posledično ne sprožijo preobčutljivostne reakcije v telesu, njihova odpornost ne bo predstavljala zapletov. Poleg tega uporaba tega pršila kot dopolnilno zdravljenje zmanjša potrebo po agresivnejših terapijah. Dolgoročna uporaba te čistilne raztopine pa tudi zmanjša pojavnost vnetij ušes in sinusov.

 



[i]  Jori A The sugar alcohols: a profile..Adv Pharmacol Chemother. 1984;20:191-218;

[ii] Mccormick Db, Touster O.The conversion in vivo of xylitol to glycogen via the pentose phosphate pathway. J Biol Chem. 1957;229(1):451-61;

[iii]  Trahan L. Xylitol: a review of its action on mutans streptococci and dental plaque--its clinical significance. Int Dent J. 1995;45(1 Suppl 1):77-92;
[iv]  Naaber P, Lehto E, Salminen S, Mikelsaar M. Inhibition of adhesion of Clostridium difficile to Caco-2 cells. FEMS Immunol Med Microbiol. 1996;14(4):205-9;
[v]  Uhari M, Kontiokari T, Niemelä M. A novel use of xylitol sugar in preventing acute otitis media. Pediatrics. 1998;102(4 Pt 1):879-84;
[vii]  Zabner J, Seiler MP, Launspach JL, Karp PH, Kearney WR, Look DC, Smith JJ, Welsh MJ. The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11614-9
[viii]  Tamura M, Hoshi C, Hori S. Xylitol affects the intestinal microbiota and metabolism of daidzein in adult male mice. Int J Mol Sci. 2013 Dec 10;14(12):23993-4007
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